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Regular cigarette smoke exposure increased the volume density of the alveolar space and reduced the alveolar septa The (Vv [a]) of the lung parenchyma increased in response to exposure to RC compared to the controls (p = 0.0078) (Table 1)

That brings us to the various designs offered

We systematically tested for the effect of bias covariates using a selection algorithm, which uses a step-wise Lasso strategy to identify statistically significant covariates at a threshold of 0.05, and adjusted for the selected bias covariates in the final model used to generate the RR estimates

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