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The evaluation of these inhaled methodologically challenging chemicals (MCCs) using in vitro systems has often relied on the application of test substances in aqueous solutions/suspensions to the apical surface of ALI models of the respiratory tract (described here as liquid application, but also commonly referred to as direct application or liquid dosing)

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[61] [62] Tobacco smoke is a complex mixture of over 7,000 identified chemicals, of which 250 are known to be harmful, at least 69 cause cancer, and 98 are known to have specific toxicological properties

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