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and carotenoids making it easier for the mouth and throat to absorb harmful chemicals, such as those from cigarette smoke, that can lead to cancer increasing blood levels of estrogen, which at high levels can cause breast cancer negatively influencing one-carbon metabolism and folate absorption, leading to DNA damage (24) How does the combination of alcohol and tobacco affect cancer risk

"Viewing alcohol drinking in the same light as cigarette smoking may well result in a decrease in consumption and its related harms."