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In cell culture experiments, Epithalon treatment has been shown to increase telomerase activity in human somatic cells, including peripheral blood T lymphocytes and retinal pigment epithelial cells

In GBM, CA9 (carbonic anhydrase 9), a downstream target gene of hypoxia-inducible factor HIF-1, has been shown to increase radiation-induced ferroptosis when it is knocked down, leading to a significant increase in intracellular ROS levels and increasing tumor cell sensitivity to radiation-induced oxidative stress ( 4.3 Ferroptosis-targeting nanomaterials In recent years, the use of nanomaterials has provided new insights into the clinical translation of ferroptosis-targeted therapy for GBM

Additionally, the expression of adipogenic differentiation markers and adiponectin was upregulated

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