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Sensitivity and subgroup analyses We conducted numerous sensitivity and subgroup analyses to investigate clinical and methodological heterogeneity and to investigate risk of bias within and across studies

low certainty).40 Pharmacotherapy and combined behavioural and pharmacotherapy interventions Our review showed that bupropion may result in little to no harm, although data were of very low certainty or could not be evaluated for certainty because not enough data were provided.22 An updated Cochrane review on bupropion41 suggested there may be a small increase in adverse events, which could constitute a small harm (Appendix 1 and Appendix 2)

The blend is made up of golden Virginia and contemporary mac Baren Cavendish tobaccos, and is smoothed by distinctive Burley