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Chronic nicotine abuse, especially if you start young during development, can also cause neuroplastic changes, including the upregulation (increase) of nicotinic receptors, which sensitizes the brain to nicotines effects and can prolong dependence [3]

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Cyp1B1 mRNA expression in correlation to cotinine levels with respect to the Cyp1B1 L432V gene polymorphism

The traditional blueprint for successfully becoming a non-smoker is staying motivated, setting a quit date, seeking support, implementing behavioral changes, and seeking professional treatment or guidance