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As the insulin receptor is expressed in all cell types and insulin signaling mediates diverse cellular functions, the detailed insulin function of each tissue has been extensively studied using tissue-specific Insr knockout mice 3,5 , in which Insr expression is almost completely disrupted in a specific cell type

The biological evidence is robust at the cellular level, and clinical results are promising but limited by small study sizes, industry sponsorship, and absence of independent replication

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Pao CI, Farmer PK, Begovic S, Goldstein S, Wu GJ, Phillips LS