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Phosphorylation of IRS1 leads to its degradation and the subsequent inhibition of Akt, resulting in increased adipose tissue lipolysis and circulating FFA levels ( The Role of ER Stress Chronic ER stress induces several pathways leading to oxidative stress, inflammation, perturbed hepatic lipid homeostasis, apoptosis, and autophagy that can lead to hepatic steatosis and its progression to NASH [reviewed in Ref

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In our future research, we will continue to investigate how modifiable risk factors combine with genetics in shaping the different forms of diabetes, as this knowledge could help improve prevention. MNT spoke with David Cutler, MD, a board certified family medicine physician at Providence Saint Johns Health Center in Santa Monica, CA, who commented that his first reaction to any study like this is to wonder whether this is simply an association or a cause-and-effect relationship