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Another compound that was identified as potent BACH1-inhibitor was the phytocannabinoid cannabidiol (CBD), which induces nuclear export and degradation of the transcription factor ( In vitro models have confirmed CBDs antioxidant and anti-inflammatory properties, acting through HMOX-1 and inducing the downregulation of pro-inflammatory cytokines (Juknat et al., 2016

Common benzodiazepines include Xanax (alprazolam), Klonopin (clonazepam), Restoril (temazepam), Ativan (lorazepam), and Valium (diazepam)

According to the Global Burden of Disease Study 2019, more than 8.5 million people globally are affected by PD (Xu et al

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