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2.3 Assessment of metE antigen immunogenicity and efficacy using in vivo aerosol MTB challenge studies Following promising results from the MGIA experiments, we then assessed whether the metE antigen, when delivered as a DNA vaccine or as a protein/adjuvant combination, could protect against an aerosol MTB challenge in mice ( Figure 5A )

FIGURE 2 2.1 Polyphenols Silymarin, the flavonoid extract from the Silybum marianum (L.) Gaertn