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The normal vascular endothelium regulates vasodilation and vasocontraction, proliferation and antiproliferation of vascular smooth muscle cells, coagulation and anticoagulation, inflammation and anti-inflammation, and oxidation and antioxidant effects, which work in balance to regulate and maintain vascular tone and structure [53]

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4.6 Study implications The finding that attitudes, rather than knowledge, were the primary correlates of vaping suggests that interventions should target the perceptual and social pathways that shape nicotine use

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