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But with a decade of use behind them, e-cigarettes are now in the crosshairs of lawmakers and leaders of local health organizations, who see them as annoyances, the vapor they produce damaging like second-hand tobacco smoke

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LR has no conflict of interest to declare and he received no financial support for participation in this study

It is symbolic that we are opening our first IQOS store in central London, just around the corner from where Mr Philip Morris opened his first tobacco shop in 1847. Our goal is to convert existing adult legal age smokers to these products and we have every intention of using todays highly efficient distribution and retail networks once a meaningful consumer demand exists. PMI has already launched IQOS in more than ten countries including Japan, Italy and Switzerland and plans to expand to cities in 20 countries by the end of 2016 and up to 35 in 2017