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A December 2018 advisory from the Surgeon General lists the dangers: In addition to nicotine, the aerosol that users inhale and exhale from e-cigarettes can potentially expose both themselves and bystanders to other harmful substances, including heavy metals, volatile organic compounds, and ultrafine particles that can be inhaled deeply into the lungs. Moreover, adolescents who vape are more likely to smoke combustible cigarettes subsequently, as compared with peers who have never used e-cigarettes, according to a review and meta-analysis of studies that assessed the link between vaping and subsequent cigarette smoking

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MY and TH joined the discussion, prepared the cellular materials, and participated in the cell death analysis, thus equally contributed to the present study