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Jonathan Foulds is a professor of public health sciences and psychiatry here at the College of Medicine, and he welcomes your question

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Your brains mesolimbic pathway becomes hijacked, prioritizing nicotines rewards over natural pleasures Your dopamine receptors gradually desensitize, requiring more nicotine to achieve the same effect Your neural circuits reshape themselves, making you increasingly vulnerable to cravings and relapse The systems adaptation involves multiple feedback mechanisms, including MAO inhibition and receptor desensitization