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In addition to traditional direct cell-to-cell contact, cells in the CNS can communicate through the paracrine action of secreted molecules or through the release and reception of extracellular vesicles, especially exosomes [259, 260]

Histological analysis of the hind limb muscle confirmed the increased number of vessels and the enhanced vascular expression of vascular endothelial growth factor receptor 2 (VEGFR2) in rat with BPC 157 treatment

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Finally, NL2 intracellular interactions with 2 subunit of GABA A R stabilize both molecules at inhibitory synapses (Dong et al., 2007)