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Lowering nicotine levels to minimally addictive or non-addictive levels would decrease the likelihood that future generations of young people become addicted to cigarettes and help more currently addicted smokers to quit. A paper published by the FDA in the New England Journal of MedicineExternal Link Disclaimer in 2018 projected that by year 2100, a potential nicotine product standard could result in more than 33 million people not becoming regular smokers, a smoking rate of only 1.4%, and more than 8 million fewer people dying from tobacco-related illnesses

Like demise of the horse and buggy, could it be that the same enslaved dopamine pathways that helped replacement nicotine appear superior in more than 200 randomized clinical trials are today, ironically, contributing to its demise

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Further limitations include possible data quality concerns