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RNA-seq studies have revealed differential expression of transporter proteins, detoxification enzymes, and stress-regulated transcription factors in response to heavy metal exposure [97]

demonstrated that Erysipelotrichia and Paenibacillus decreased mucus permeability, whereas Proteobacteria and Saccharibacteria increased it, highlighting that mucus properties are strongly influenced by microbiota composition (60)

Current therapeutic approaches for IVDD encompass pharmacological management, physical modalities, and surgical interventions

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