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Nonetheless, snus use has been positively associated with incidence and, particularly, mortality of CVD in a number of studies [Citation1014]

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However, the researchers noted that the study had several limitations to be considered including that the meta-analysis was based on observational studies, that PNE had the potential to be misclassified due to most of the studies being based on self-reported data, and that there was high statistical heterogeneity across the studies

The new study used data from the Global Youth Tobacco Survey, a World Health Organization program that periodically asks a nationally representative sample of school kids about their recent tobacco-smoking behaviors