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Active smoking can increase total IgE serum concentration and ex-smokers show a decline in serum IgE concentration after cessation of smoking (Burrows et al., 1981)

A recent meta-analysis of cerebrospinal fluid (CSF) and plasma biomarkers have confirmed increased levels of IL-6, TNF-, and other pro-inflammatory cytokines across AD cohorts, further supporting a role for persistent immune activation (89)