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Medical supervision requirement: All AOD-9604 therapy requires comprehensive physician oversight including baseline health assessment and laboratory work, informed consent regarding research-purposes-only status, regular monitoring of body composition and metabolic markers, dose adjustments based on individual response, and integration with comprehensive health optimization strategies

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There have been postmarketing reports of renal impairment, acute kidney injury, and worsening of chronic renal failure, which sometimes has required hemodialysis, in patients treated with GLP-1 receptor agonists

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