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A dose-related relationship between increased risk and heaviness of smoking has been shown for spontaneous pregnancy loss, LBW, placental abruption, and stillbirth

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low certainty).40 Pharmacotherapy and combined behavioural and pharmacotherapy interventions Our review showed that bupropion may result in little to no harm, although data were of very low certainty or could not be evaluated for certainty because not enough data were provided.22 An updated Cochrane review on bupropion41 suggested there may be a small increase in adverse events, which could constitute a small harm (Appendix 1 and Appendix 2)

A detailed description of serum total testosterone testing can be found at: and Covariates Based on previous literature 20,21,22,23 and clinical practice, confounders were selected