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Conversely, bupropion may decrease the renal excretion rate of sitagliptin, saxagliptin, and canagliflozin which could result in higher serum concentration

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The dose-response relationship between smoking and cardiovascular mortality is non-linear, suggesting that reduction in HPHC concentrations in e-cigarette aerosols may not result in proportional harm reduction and decreased HPHC exposure may be offset by increased use by individuals who believe that e-cigarettes are safer than conventional cigarettes