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The rugged and independent image of the cowboy became synonymous with the Marlboro brand, capturing the imagination of consumers across the nation

La nicotina puede afectar cmo responde el cerebro al estrs, al miedo y a la ansiedad

The buccal route has always been the most advantageous route for nicotine administration since the drug can reach the systemic circulation without being degraded by gastrointestinal and hepatic first-pass metabolism (56,57)

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