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Later, the central and peripheral nervous system are also disturbed, because vitamin B12 is jointly responsible for the formation of the myelin sheaths of the nerve cells

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This discrepancy could be justified with the subgroups of the MB treated, but this detail is not reported in the original article (310) Also, using nivolumab in a little series of CNS tumors (with just one MB), it appears that a difference in the median survival was associated with the expression of PDL1 and high tumor mutation burden (311)