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It is not an understatement to say that she is the backbone of the entire operation, running our lives, brains and words with a ruthless brilliance

We dont agree on everything, and I would never expect us to

Glossary ADHD attention-deficit/hyperactivity disorder CD conduct disorder CI confidence interval DSM-IV Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition HR hazard ratio ND nicotine dependence OR odds ratio Footnotes Dr Schoenfelder co-conceptualized and designed the study, extracted data, conducted analyses, and drafted the initial manuscript

In contrast to his designs for Chanel (which are fragile, poetic, and feminine) and Fendi (which have a kind of hard-edged extroversion), those for his Karl Lagerfeld line are often sombre, reflecting the gray skies and bleakness of rural northern Germany, where he grew up