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This masking effect is why people often consume toxic amounts of alcohol without realizing it until the stimulant wears off, at which point the full force of the alcohol hits them at once, often leading to alcohol poisoning or an overdose

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So Selye began to suggest that subjecting an animal to prolonged stress led to tissue changes and physiological changes with the release of certain hormones, that would then cause disease and ultimately the death of the animal." And so the idea of stress and it's potential costs to the body was born