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It is easily accessible and can be extracted using mature methods like acid hydrolysis, alkali hydrolysis, fermentation, and enzymatic processes, which are relatively low-cost and suitable for large-scale application (Simn et al., 2020)

The ASM is activated by several cellular stresses implicated in both apoptosis and autophagy by modulating the balance between ceramide and its metabolic derivatives, sphingosine (Sph) and sphingosine-1-phosphate (S1P) (Lee et al., 2014)

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-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors