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Although a leading risk factor for non-communicable diseases (NCDs), its burden has been systematically underestimated in global health metrics 12,13

In a study of 124 patients admitted for acute myocardial infarction [87] who reported marijuana use and controlled for other triggers, there was a 4.8-fold increase in the risk of myocardial infarction (95% confidence interval [CI] 2.49.5, p = 0.001) in the first hour following marijuana use as compared with periods of non-use

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After the tax increase several started using the big tobacco processes like expanded tobacco to get the same volume in less weight (thus lowering the tax hit)