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According to Ramachandran Nair, L.s 2019 study, Targeting the 42- and 7-Subtypes of Nicotinic Acetylcholine Receptors for Smoking Cessation Medication Development, the 42 nicotinic acetylcholine receptors account for approximately 95% of the total nAChR population in the brain and play a critical role in mediating the primary reinforcing actions of nicotine

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