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In a May 2007 report on reducing tobacco use in the United States, the IOM concluded that while strengthening existing tobacco control measures (e.g., state anti-smoking programs, excise taxes, indoor smoking restrictions) would result in some additional decline in smoking prevalence, more substantial and enduring reductions in tobacco use would only come from stronger federal regulation

[15] Early modern European medical science was still to a great extent based on humorism, the idea that everything had a specific humoral nature that varied between hot and cold, dry and moist