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On 15 April 2014, Imperial Tobacco announced that the Horizon factory would close in early 2016, bringing an end to cigarette and tobacco manufacture in Nottingham after over 130 years

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Oral microbial dysbiosis, coupled with gingival inflammation, has been linked to adverse pregnancy outcomes such as low birth weight, preterm birth, preeclampsia, and pregnancy loss 3,7,8,9,10