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Although no combustion is involved, the nicotine is still derived from tobacco

10.1177/026119291604400206 4 BehrsingH.HillE.RaabeH.TiceR.FitzpatrickS.DevlinR.et al (2017)

Implications Current cigarette packaging warnings in combination with novel warnings on individual cigarette sticks, are considered helpful strategies for smoking control

In mice, skin MCs are almost exclusively MrgprB2 + connective tissuetype cells of embryonic origin that persist independently of bone marrow renewal (60), whereas in humans, at least four distinct clusters (MC1MC4) are enriched in the skin, including MC1 as a dominant subset with distinct effector programs and spatial associations (61)