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For this process to work, the product needs to generate extremely high temperatures

- Cons: - Skill and Practice: Hand-rolling requires practice to master the technique and achieve consistent results in terms of tightness, density, and even burn

Thus, it can be argued that a defect leading to increased CVD risk in smokers is insulin resistance and that the multiple adverse consequences associated with insulin resistance, including dyslipidemia and endothelial dysfunction, are responsible for the accelerated atherogenesis in these individuals (86)

Conventional laser perforation Possible to perforate by pulsed and focused laser beams are holes sizes from 60 to 200 m at density of holes of typical 10 to 30 holes per cm length, holes sequences up to 400.000 holes per second at a maximum of 32 hole rows by laser distributed over the width of the web with traditional systems or machines on the market