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Decades of daily smoking cause progressive and often irreversible damage to the chest and lungs. Long term exposure to tobacco smoke leads to chronic inflammation, loss of lung elasticity, reduced oxygen exchange, and Cigarette smoke triggers increased ACE 2 expression in the lung Immunopaedia Increased Inflammation and Disease Activity Among Current Cigarette Smokers with RA Oxidative stress and inflammation: elucidating mechanisms of smoking attributable pathology for therapeutic targeting Bulletin of the National Research Centre Springer Nature Link

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