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Interestingly, the structure of a base excision repair polymerase in complex with the N 2 -dG adduct of the benzo[ c ]phenanthrene (BPh) diol epoxide also shows the adduct in a similar conformation as in free DNA 58

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After oral administration, NAC is rapidly absorbed from the gastrointestinal tract, and in the liver, it is transformed through deacetylation to cysteine, which (1) is used for glutathione (GSH) production, (2) enters the bloodstream and crosses the bloodbrain barrier [17, 18] using a sodium-dependent transport system

Yet differential expression of components of the processes in particular neuronal systems may account for selective neurodegeneration in certain disorders. In short, the same pathological process can result in a different constellation of symptoms and therefore result in a range of eventual diagnoses