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Glutamate, cysteine, and glycine are the three primary amino acids constituting GSH, with cysteine acquisition being the most pivotal ( 3.2.2 The Met/cystine cycle and other amino acid pathways Beyond the direct uptake of extracellular cystine, cells can also generate cysteine via the methionine (Met) cycle and transsulfuration pathway ( 3.2.3 Amino acid derivatives and joint protection Certain amino acidderived small molecules, such as N-acetylcysteine (NAC) and taurine, have notable antioxidant and anti-inflammatory properties ( 3.3 Iron metabolic reprogramming 3.3.1 Alterations in proteins governing iron uptake, storage, and export Ferroptosis is closely associated with dysregulated iron homeostasis, in which intracellular iron accumulation facilitates lipid peroxidation and cell death

Pedlar CR, Brugnara C, Bruinvels G, et al

& Sung, J