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Importantly, these findings provide a mechanistic explanation for the limited diagnostic value of circulating zinc measurements and the variable clinical efficacy of nonspecific zinc supplementation, which fail to capture or correct compartment-resolved zinc dysregulation

Pregnant and breastfeeding individuals have increased requirements for many B vitamins, and indeed these vitamins are routinely included in prenatal supplements

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Many had obesity or diabetes, and no consideration was given to race, ethnicity, socioeconomic status, or habits such as smoking or alcohol consumption