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However, in the United States, about 10% of patients with Lyme arthritis develop persistent synovitis, which lasts for months or even several years after the apparent eradication of the spirochete from the joint with antibiotic therapy

Lack of vitamin D in elderly subjects is associated with the pro-inflammatory phenotype of immune cells, which is likely to contribute to an increased risk of developing a serious infection in older individuals

doi: 10.3389/fphys.2020.577856 Received 01 July 2020 Accepted 25 August 2020 Published 11 September 2020 Volume 11 - 2020 Edited by Carol Ann Remme, University of Amsterdam, Netherlands Reviewed by Gary David Lopaschuk, University of Alberta, Canada