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The etiology of CRC is associated with various factors, including age, sex, inflammatory bowel disease, lifestyle and environmental factors (35)

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Among them, the MC3181 derivative was recently found to be extremely efficient in blocking cancer growth and metastasis in a xenograft mouse model of vemurafenib resistant melanoma (Fig

Iron overload may not be a central driver of ferroptosis in these disorders, which challenges current assumptions about the physiological triggers of ferroptosis in vivo [35]