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Downstream IGF-1 elevation persists considerably longer because hepatic IGF-1 production continues after the peptide itself has cleared [4]

However, these sites are enriched for CpG (99.3%) islands and almost half of the probes on the array cover intergenic regions, such as bioinformatically predicted enhancers, DNase I hypersensitive sites and validated differentially methylated regions (DMRs).60 61 However, the HM450 platform may miss important regulatory regions

Therefore, comprehensive and long-term toxicological assessments are warranted to better understand their safety and guide regulatory frameworks (Balusamy et al., 2023