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However, a significant question remains about whether these associations represent predisposing features for the risk of developing cigarette smoking or are consequences of cigarette smoking. Specifically, they looked over data on health behaviors, brain scans, and genetic risk factors, all drawn from the dataset known as the UK Biobank, and then performed statistical analysis to see if daily smoking led to decreased brain volume over time

And then smokers are noted to have higher rates of chemotherapy-related toxicity, which we do know can also relate to some complications for treatment

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