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5.1 The therapeutic potential of decreasing copper bioavailability in tumor In recent years, it has been increasingly recognized that compared to most other tissues, tumor cells have an increased demand for copper, which represents a metabolic vulnerability that can be exploited by limiting the availability of copper (167)

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During pulldown experiments to identify TG2-interacting proteins and to analyze domaindomain interactions, lysates from cells that express a high level of TG2 exhibited an increase in aggregate formation

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