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Managing these side effects can be challenging for many individuals, particularly due to the drugs addictive properties

As a delivery carrier of bone marrow mesenchymal stem cells, this hydrogel protects the implanted cells from ROS and hypoxia-mediated death, significantly enhances their osteogenic potential, and simultaneously downregulates local inflammatory factors, ultimately achieving better bone integration and arthritis relief

However, intermittent fasting lasting less than 48 h did not demonstrate such beneficial effects compared to longer-term caloric restriction 50

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