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Of these two, itraconazole has most promise as a pharmaceutical invention targeting NPC1, since it is already included in several clinical trials as an anti-cancer drug due to its ability to inhibit hedgehog pathway as well as due to its various anticancer activities including its ability to target multidrug resistance via ABC transporters [120]

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Among these proteins, is the serum- and glucocorticoid-dependent kinase (Waldegger et al., 1997), which is now recognized for its role in promoting hepatic insulin resistance (Zhou et al., 2021)

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