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Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis

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very popular among YAMS [young adult male smokers], nicely complements F1 as a Marlboro property. The Marlboro brand has indeed had a longstanding relationship with Formula One that has caused tension between governing bodies and anti-smoking advocates