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In addition, the anti-NGF antibody pretreatment abolished the previously observed changes in the levels of the gclm and nrf2 mRNAs ( gclm , nrf2 , and genes involved in AA transport systems that are responsible for the uptake of L-cys/L-cys 2 in the striatum in different cell types such as endothelial, astrocytes, microglia, and neurons

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Present genetic research appears to connect reduced orotate production to abnormalities in the dihydroorotate dehydrogenase (DHODH) gene, which causes human Miller syndrome