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In order to limit ROS production and mitigate potential damage, cells have developed a wide range of antioxidant systems, including superoxide dismutase, catalase, glutathione peroxidase, vitamin E, and vitamin C

Oncotarget 8 , 1105311062 (2017)

Furthermore, CCS expression is strongly negatively correlated with copper levels, serving as a feedback regulatory mechanism to prevent excessive activation of SOD1 under conditions of copper overload (37)