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[64] Such an activatable antibody construct may be an antibody or an antigen binding fragment thereof that typically comprises (i) at least two binding domains each comprising a heavy chain amino acid sequence and a light chain amino acid sequence, (ii) a masking moiety that inhibits the binding of each binding domain in an uncleaved state to the respective binding partner such as a target cell surface, and (iii) a cleavable moiety positioned between (i) and (ii), wherein the cleavable moiety is a polypeptide that functions as a substrate e.g

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Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice

This role is crucial, especially considering the potential adverse effects of visceral fat accumulation, like insulin resistance and cardiovascular disease, on overall health