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Harrisons Principles of Internal Medicine

We then treated new NT2-N cells with positive (medication cocktail) control, negative control (vehicle), and 960 off-patent compounds from the Prestwick library ( Based on the changes in gene expression, a similarity score for each drug relative to the medication cocktail was calculated

Interestingly, there was no significant difference in the levels of GSH content (0.70 to 0.82 mg/g protein) within the experimental groups (G2, G3, G4) whereas, significantly different from NC and G1 as the former had very high GSH level while the latter had very low levels ( P value = 0.0002)

The mechanisms appear to involve enhanced blood flow, antioxidant effects, and support of hepatocyte regeneration