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When these two pathways are activated simultaneously, the effect is multiplicative: GHRH increases the amount of GH released per cell, and GHRP increases the number of responding cells

The researchers concluded that impaired GH secretion in aging is a functional and potentially reversible state, not a permanent decline

Thus, experimental studies have shown that mice lacking GH secretion or GH receptors live longer than wild-type mice, contradicting the idea of GH as an anti-aging hormone and supporting the concept of growth acceleration as a determinant of life potential